COMPUTATIONAL BIOLOGY AND IMMUNO-ONCOLOGY (CBIO)

Research

We are developing and using computational approaches for integrative analyses of multi-omics and next-generation sequencing data in order to gain a network-level view of the studied system for a variety of applications. We aim to predict and test novel drug targets, biomarkers, and biological mechanisms (e.g. immune escape) to treat cancer more effectively with a focus on cancer immunology based therapeutic solutions.

Using clinical data, immuno-genomic analyses, pharmacogenomics databases, machine learning approaches, and integrative data science strategies we aim to contribute to 1) personalized medicine and precision oncology, and 2) systems and network medicine, therapy resistance and vulnerabilities.

Specific research questions are related to:

– Connection of DNA damage and repair with the immunome in (ovarian) cancer
– Systems analysis of microRNA-mRNA networks and alternative splicing shaping the tumor immune environment and other disease processes
– Prediction of tumor specific and viral antigens for therapeutic vaccination
– Soluble and tissue based predictive and prognostic biomarker
– Spatial and single cell analyses of the tumor microenvironment
– Immunomodulation by intratumoral microbiome/mycobiome

Team

Alumni

Lukas Küng, Falk Gogolla, Markus Ausserhofer, Hendrik Gottschling, Miriam Federer, Matthias Leitner, Christoph Schatz

Projects

 – MUI/UIBK PhD program: Antimycotic resistance – approach from a one health perspective – MYCOS (Immunomodulation by intratumoral mycobiome)
 – OeNB Anniversary fund (PI): Connection of DNA damage and repair with the immunome in high grade serous ovarian cancer
 – FWF Austrian Science Fund (Co-PI): MicroRNAs as predictive biomarker for COVID-19
 – Pharmaceutical & Biotech company partners: Computational cancer immunology

News and reports

Reversing resistance to cancer immunotherapy. 2025

AI and Scientific Computing in Medicine (AISCM) at the Medical University of Innsbruck

Monfort-Lanzas P et al. Aplications of artificial intelligence in immuno-oncology (Book chapter). 2025

May M. Immunogenomics is on the Way Up. Inside precision medicine. 2024

Hautz T et al. Transcriptomic signatures during normothermic liver machine perfusion. eBioMedicine. 2024 (MUI news)

Publications

2026

Gil-Barrachina M, Hernando B, Perez-Pastor G, Alegre-de-Miquel V, Valenzuela-Oñate C, Minguez-Lujan S, Monfort-Lanzas P, Tomas-Bort E, Marques-Torrejon MA, Martinez-Cadenas C. Genetic Evolution of Melanoma: Comparative Analysis of Candidate Gene Mutations in Healthy Skin, Nevi, and Tumors from the Same Patients.Int J Mol Sci. 2026. 27:532. https://doi.org/10.3390/ijms27010532

Dingfelder J, Pereyra D, Riha M, Becker N, Rauter L, Hackl H, Müller JF, Hammer-Purgstall F, Aiad M, Eichelter J, Starlinger P, Silberhumer GR, Salat A, Berlakovich GA, Györi G, Soliman T. HTK is a viable UW alternative for hypothermic oxygenated machine perfusion of liver grafts supporting a single-solution protocol. J Clin Med. 2026. 15:112. https://doi.org/10.3390/jcm15010112

2025

Melero I, de Miguel Luken MJ, de Velasco G, Garralda E, Martin-Liberal J, Joerger M, Alonso G, Goebeler ME, Schuler M, König D, Dummer R, Reig M, Rodriguez-Ruiz M,Calvo E, Esteban-Villarrubia J, Oberoi A, Sàbat P, Soto-Castillo JJ, Koster KL, Saavedra O, Sayehli C, Gromke T, Läubli H, Ramelyte E, Fortuny M, Landa-Magdalena A, Moreno I, Torres-Jiménez J, Hernando-Calvo A, Hess D, Racca F, Richly H, Schmitt A, Eggenschwiler C, Sanduzzi-Zamparelli M, Vilalta-Lacarra A, Trojan J, Koch C, Galle P, Foester F, Trajanoski Z, Hackl H, Gogolla F, Koll F, Wild P, Chun FK, Reis H, Lloyd P, Machacek M, Gajewski TF, Fridman W, Eggermont A, Bargou R, Schöniger S, Rüschoff J, Tereshchenko A, Zink C, de Silva A, Lichtenegger F, Akdemir J, Rüdiger M, L’Huillier P, Dutta A, Haake M, Wischhusen J, Auckenthaler A, Gjorgjioska A, Rössler B, Hermann F, Liebig M, Reichhardt D, Schuberth-Wagner C, Fettes P, Auer M, Klar K, Leo E. Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours. Nature. 2025. 637:1218-1227. https://doi.org/10.1038/s41586-024-08305-z

Steger K, Fiegl H, Rungger K, Leitner K, Tsibulak I, Feroz B, Ebner C, Marth C, Hackl H*, Zeimet AG*. The role of plasmacytoid dendritic cells in the immune contexture of TP53-mutated high-grade serous ovarian cancer. Cancers. 2025. 17:3877. https://doi.org/10.3390/cancers17233877

Amor M, Diaz M, Fürlinger A, Svecla M, Bianco V, Dobrijević A, Akhmetshina A, Vujić N, Schooltink L, Korbelius M, Hirtl M, Bürger M, Pirchheim A, Schwarz B, Rainer S, Schauer S, Beretta G, Goessler W, Kolb D, Hoefler G, Hackl H, Madreiter-Sokolowski C, Abdellatif M, Norata GN, Kratky D. Deletion of MMP12 improves energy metabolism and brown adipose tissue function in mice prone to cardiometabolic diseases. J Lipid Res. 2025. https://doi.org/10.1016/j.jlr.2025.100951

Danklmaier S, Vijver SV, Pipperger L, Floriani G, Perro L, Konrad V, Hofer T, Hackl H, Das K, Wollmann G. Newly identified oncolytic VSV-GP-specific CD8+ T cell epitopes for monitoring of anti-viral immune responses in the BALB/c mouse model. Mol Ther Oncol. 2025. 33:201072. https://doi.org/10.1016/j.omton.2025.201072

Rumpf B, Santol J, Kern AE, Ammann M, Probst J, Baumgartner R, Jankoschek AS, Podrascanin V, Lehner F, Huber FX, Pereyra D, Ortmayr G, Dong Y, Petschnak S, Wolf B, Assinger A, Hackl H, Gilg S, Gruenberger T, Starlinger P. PNPLA3 polymorphism worsens chemotherapy associated liver injury and affects overall survival in colorectal cancer patients with liver metastasis undergoing hepatic resection. EBioMedicine. 2025. 120:105928. https://doi.org/10.1016/j.ebiom.2025.105928

Bauer M, Vaxevanis C, Jaekel N, Hackl H, Wilfer A, Zoellig C, Haemmerle M, Müller-Tidow C, Al-Ali HK, Seliger B, Wickenhauser C. Association of the composition of the bone marrow tumor microenvironment in BCR::ABL1-negative myeloproliferative neoplasms with IFN-g signaling and driver mutations. Leukemia. 2025. 39. 2391–2405. https://doi.org/10.1038/s41375-025-02706-3

Dong Y, Gregory LA, Podrascanin V, Santol J, Ammann M, Pereyra D, Hackl H, Li Z, Truty MJ, Warner SG, Smoot RL, Gruenberger T, Nagorney DM, Starlinger PP. Preoperative von Willebrand Factor is an independent predictive biomarker for posthepatectomy liver failure – a multivariable model with APRI+ALBI. Liver Transpl. 2025. https://doi.org/10.1097/lvt.0000000000000676

Mehic D, Pirabe A, Schrottmaier W, Schmuckenschlager A, Fruehwirth S, Hackl H, Tolios A, Ay C, Gebhart J, Pabinger I, Asssinger A. Impaired surface receptor expression on immature platelets in bleeding patients with abnormal light transmission aggregometry. J Thromb Haemost. 2025. 23:2982-2989. https://doi.org/10.1016/j.jtha.2025.05.011

Ranches G, Hackl H, Zaderer V, Ploner M, Posch W, Wilflingseder D, Kummer K, Hüttenhofer A*. Differentially expressed ncRNAs as key regulators in infection of human bronchial epithelial cells by the SARS-CoV-2 Delta variant. Mol Ther Nucleic Acids. 2025. 36:102559. https://doi.org/10.1016/j.omtn.2025.102559

Guerrero-Navarro L, Monfort-Lanzas P, Krichbaumer V, De Araújo MEG, Monfregola J, Huber LA, Ballabio A, Jansen-Dürr P, Cavinato M. TFEB Orchestrates Stress Recovery and Paves the Way for Senescence Induction in Human Dermal Fibroblasts. Aging Cell. 2025. 24:e70083. https://doi.org/10.1111/acel.70083

Rusu EC, Clavero-Mestres H, Sánchez-Álvarez M, Veciana-Molins M, Bertran L, Monfort-Lanzas P, Aguilar C, Camaron J, Auguet T. Uncovering hepatic transcriptomic and circulating proteomic signatures in MASH: A meta-analysis and machine learning-based biomarker discovery. Comput Biol Med. 2025. 191:110170. https://doi.org/10.1016/j.compbiomed.2025.110170

Monfort-Lanzas P, Gostner JM, Hackl H. Modeling omics dose-response at the pathway level with DoseRider. Comput Struct Biotechnol J. 2025. 27:1440-1448. https://doi.org/10.1016/bs.mcb.2025.03.007

Hofer S, Jenny M, Klein A, Becker K, Parráková L, Überall F, Ganzera M, Fuchs D, Hackl H, Monfort-Lanzas P, Gostner JM. Myrobalan fruit extracts modulate immunobiochemical pathways in vitro. Antioxidants. 2025. 14:350. https://doi.org/10.3390/antiox14030350

Monfort-Lanzas P, Rungger K, Madersbacher L, Hackl H. Machine learning to dissect perturbations in complex cellular systems. Comput Struct Biotechnol J. 2025. 27:832-842. https://doi.org/10.1016/j.csbj.2025.02.028

Steger K, Fiegl H, Feroz B, Leitner K, Marth C, Hackl H, Zeimet AG. Differences in immunogenicity of TP53-mutated cancers with low tumor mutational burden (TMB) – A study on TP53mut endometrial-, ovarian- and triple negative breast cancer. Eur J Cancer. 2025. 219:115320. https://doi.org/10.1016/j.ejca.2025.115320

Graber M, Gollmann-Tepeköylü C, Schweiger V, Hirsch J, Pölzl L, Nägele F, Hackl H, Sopper, S, Kirchmair E, Mair S, Voelkl J, Plattner C, Eichin F, Trajanoski Z, Krogsdam A, Eder J, Fiegl M, Hau D, Tancevski I, Grimm M, Cooke JP, Holfeld J. Modulation of cell fate by shock wave therapy in ischemic heart disease. Eur Heart J Open. 2025. 5:oeaf011. https://doi.org/10.1093/ehjopen/oeaf011

Jonas JP, Müller PC, Linecker M, Hackl H, Santol J, Eshmuminov D, Rössler F, Ammann M, Ignatavicius P, Guidetto C, Sander S, Ardiles V, Wen Z, Romic I, Fronek J, Kysela M, Truant S, Oldhafer K, Reese T, Rauchfuss F, Ulmer TF, Wahba R, Hahn O, Di Benedetto F, Fernandez-Placencia R, Robles-Campos R, Lopez Lopez V, Sparrelid E, Petrowsky H, Clavien PA, Starlinger P. Optimization of ALPPS stage II timing with the APR/ALBI score – an international, multicenter cohort study. Hepatobiliary Surg Nutr. 2025. 14:742-754. https://doi.org/10.21037/hbsn-24-617

2024

Pirabe A, Mehic D, Hackl H, Frühwirth S, Schmuckenschlager A, Beck S, Gebhart J, Gleixner K, Sperr W, Schrottmaier WC, Assinger A. Impaired hemostatic and immune functions of platelets after acute thrombocytopenia. J Thromb Haemost. 2024. 23:1052-1065. https://doi.org/10.1016/j.jtha.2024.11.029

Ammann M, Adjei Antwi SK, Gudmundsdottir H, Hackl H, Santol J, Guillot BE, Pappalettera G, Thiels CA, Warner SG, Trury MJ, Kendrick ML, Smoot RL, Nagorney DM, Cleary SP, Halfdanarson TR, Starlinger P. Surgical and oncologic outcomes for liver resections of cystic neuroendocrine tumor liver metastasis. Eur J Surg Oncol. 2025. 51:109464. https://doi.org/10.1016/j.ejso.2024.109464

Gronauer R, Madersbacher L, Monfort-Lanzas P, Floriani G, Sprung S, Zeimet AG, Marth C, Fiegl H, Hackl H. Integrated immuno-genomic analyses of high-grade serous ovarian cancer reveal vulnerability to combination immunotherapy. Front Immunol. 2024. 15:1489235. https://doi.org/10.3389/fimmu.2024.1489235

Ammann M, Jonas JP, Pereyra D, Santol J, Hackl H, Kalchbrenner T, Laengle J, Podrascanin V, Lehner F, Viragos-Toth IL, Hulla W, Ruso V, Smoot RL, Gruenberger T, Assinger A, Starlinger P. Plasma GLP-1 and metabolic dynamics during human liver regeneration and their association with posthepatectomy liver failure. Hepatobiliary Surg Nutr. 2025. 14:49-65. https://doi.org/10.21037/hbsn-24-464

Breithofer J, Bulfon D, Fawzy N, Tischitz M, Zitta C, Hartig L, Grabner GF, Pirchheim A, Hackl H, Taschler U, Lass A, Tam-Amersdorfer C, Strobl H, Kratky D, Zimmermann R. Phospholipase A2 group IVD mediates the transacylation of glycerophospholipids and acylglycerols. J Lipid Res. 2024. 65:100685. https://doi.org/10.1016/j.jlr.2024.100685

Resch U, Hackl H, Pereyra D, Santol J, Brunnthaler L, Probst J, Jankoschek AS, Aiad M, Nolte H, Krueger M, Starlinger P, Assinger A. SILAC-based characterization of plasma-derived extracellular vesicles in patients undergoing partial hepatectomy. Int J Mol Sci. 2024. 25:10685. https://doi.org/10.3390/ijms251910685

Mildner FO, Sykora MM, Hackl H, Amann A, Zelger B, Sprung S, Buch ML, Nocera F, Moser P, Maier H, Augustin F, Manzl C, Kocher F, Pircher A, Lindenmannm J, Mykoliuk I, Raftopoulou S, Kargl J, Wolf D, Sopper S, Gamerith G. Soluble PD-L1 shows no association to relapse and overall survival in early stage non-small cell lung cancer (NSCLC). Lung Cancer. 2024. 196:107955. https://doi.org/10.1016/j.lungcan.2024.107955

Hautz T, Hackl H, Gottschling H, Gronauer R, Hofmann J, Salcher S, Zelger B, Oberhuber R, Cardini B, Weissenbacher A, Resch T, Troppmair J, Schneeberger S. Transcriptomic signatures during normothermic liver machine perfusion correspond with graft quality and predict the early graft function. EBioMedicine. 2024. 108:105330. https://doi.org/10.1016/j.ebiom.2024.105330

Amor M, Diaz M, Bianco V, Svecla M, Schwarz B, Rainer S, Pirchheim A, Schooltink L, Mukherjee S, Grabner G, Beretta G, Lamina C, Norata GD, Hackl H, Kratky D. Identification of regulatory networks and crosstalk factors in brown adipose tissue and liver of cold-exposed cardiometabolic mouse model. Cardiovasc Diabetol. 2024. 23:298. https://doi.org/10.1186/s12933-024-02397-7

Hargitai R, Parráková L, Szatmári T, Monfort-Lanzas P, Galbiati V, Audouze K, Jornod F, Staal Y, Burla S, Chary A, Gutleb A, Lumniczky K, Vandebriel R, Gostner JM. Chemical respiratory sensitization – Current status of mechanistic understanding, knowledge gaps and possible identification methods of sensitizers. Front Toxicol. 2024. 6:1331803. https://doi.org/10.3389/ftox.2024.1331803

Brandt MP, Vakhrusheva O, Hackl H, Daher T, Tagscherer K, Roth W, Tsaur I, Handle F, Eigentler A, Culig Z, Thomas C, Erb HH, Haferkamp A, Jüngel E, Puhr M. Inhibition of the sterol regulatory element binding protein (SREB-P) SREBF-1 overcomes docetaxel resistance in advanced prostate cancer. Am J Pathol. 2024. https://doi.org/10.1016/j.ajpath.2024.07.019

Bauer M, Monecke A, Hackl H, Wilfer A, Jäkel N, Bläker H, Al-Ali H, Seliger B, Wickenhauser. Association of immune evasion in myeloid sarcomas with disease manifestation and patients’ survival. Front Immunol. 2024. 15:1396187. https://doi.org/10.3389/fimmu.2024.1396187

Brunnthaler L, Hammond T, Pereyra D, Santol J, Probst J, Laferl V, Resch U, Aiad M, Janoschek AS, Gruenberger T, Hackl H, Starlinger P, Assinger A. HMGB1-mediated cell death – a crucial element in post-hepatectomy liver failure. Int J Mol Sci. 2024. 25:7150. https://doi.org/10.3390/ijms25137150

Monfort-Lanzas P, Rusu CE, Parrakova L, Karg CA, Kernbichler DE, Rieder D, Lackner P, Hackl H, Gostner JM. ExonSurfer: A web-tool to design primers at exon-exon junctions. BMC Genomics. 2024. 25:594. https://doi.org/10.1186/s12864-024-10456-2

Ammann M, Gudmundsdottir H, Hackl H, Antwi SKA, Santol J, Habermann EB, Thiels CA, Warner SG, Truty MJ, Kendrick ML, Smoot RL, Nagorney DM, Cleary SP, Halfdanarson TR, Starlinger PP. Neuroendocrine Tumors of Unknown Primary in the Setting of Cytoreductive Hepatectomy. Ann Surg Oncol. 2024. 31:4931-4941. https://doi.org/10.1245/s10434-024-15374-x

Feroz B, Pan TL, Leitner K, Ebner C, Steger K, Kildal W, Kristensen GB, Zeimet AG, Hackl H, Fiegl H, Marth C, Wieser V. Tumoral PD1 expression in endometrial carcinoma is a prognostic marker for patient outcome. Int J Gynecol Cancer. 2024. 34:1711-1718. https://doi.org/10.1136/ijgc-2023-005188

Rusu EC, Monfort-Lanzas P, Bertran L, Barrientos-Riosalido A, Solé E, Mahmoudian R, Aguilar C, Briansó S, Mohamed F, Garcia S, Camaron J, Auguet T. Towards understanding post-COVID-19 condition: a systematic meta-analysis of transcriptomic alterations with sex-specific insights. Comput Biol Med. 2024. 175:108507. https://doi.org/10.1016/j.compbiomed.2024.108507

Mazziotta F, Biavati L, Cataquiz Rimando J, Rutella S, Borcherding N, Parbhoo S, Mukhopadhyay R, Knaus HA, Valent P, Hackl H, Borrello I, Blazar BR, Hatzi K, Gojo I, Luznik L. CD8+ T-cell differentiation and dysfunction inform treatment response in acute myeolid leukemia. Blood. 2024. 144:1168–1182. https://doi.org/10.1182/blood.2023021680

Jaylet T, Coustillet T, Smith NM, Viviani B, Lindeman B, Vergauwen L, Myhre O, Yarar N, Gostner JM, Monfort-Lanzas P, Jornod F, Holbech H, Coumoul X, Sarigiannis DA, Antczak P, Bal-Price A, Fritsche E, Kuchovska E, Stratidakis AK, Barouki R, Kim MJ, Taboureau O, Wojewodzic MW, Knapen D, Audouze K. Comprehensive mapping of the AOP-Wiki database: identifying biological an disease gaps. Front Toxicol. 2024. 6:1285768. https://doi.org/10.3389/ftox.2024.1285768

2023

Taenzer M, Löffler-Ragg J, Schroll A, Monfort-Lanzas P, Engl S, Weiss G, Brigo N, Kurz K. Urine Metabolite Analysis to Identify Pathomechanisms of Long COVID: A Pilot Study. Int J Tryptophan Res. 2023. 16:11786469231220781. https://doi.org/10.1177/11786469231220781

Eigentler A, Handle F, Schanung S, Degen A, Hackl H, Erb HH, Fotakis G, Hoefer J, Ploner C, Jöhrer K, Heidgger I, Pircher A, Klotz W, Herold M, Schaefer G, Culig Z, Puhr M. Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts. Oncogene. 2023. 43:235-247. https://doi.org/10.1038/s41388-023-02901-5

Koeck S, Amann A, Kern J, Zwierzina M, Lorenz E, Sopper S, Zwierzina H, Mildner F, Sykora M, Sprung S, Hackl H, Pircher A, Pall G, Wolf D, Gamerith G. Whole stromal fibroblast signature is linked to specific chemokine and immune infiltration patterns and to improved survival in NSCLC. Oncoimmunology. 2023. 12:2274130. https://doi.org/10.1080/2162402x.2023.2274130

Santol J, Kim S, Gregory LA, Baumgartner R, Murtha-Lemekhova A, Birgin E, Gloor S, Braunwarth E, Ammann M, Starlinger J, Pereyra D, Ammon D, Ninkovic M, Kern AE, Rumpf B, Ortmayr G, Herrmann Y, Dong Y, Huber FX, Weninger J, Thiels CA, Warner SG, Smoot RL, Truty MJ, Kendrick ML, Nagorney DN, Cleary SP, Beldi G, Rahbari NN, Hoffmann K, Gilg S, Assinger A, Gruenberger T, Hackl H, Starlinger P. An APRI+ALBI based multivariable model as preoperative predictor for posthepatectomy liver failure. Ann Surg. 2023. https://doi.org/10.1097/sla.0000000000006127

Pirabe A, Frühwirth S, Brunnthaler L, Hackl H, Schmuckenschlager A, Schrottmaier WC, Assinger A. Age dependent surface receptor expression pattern in immature versus mature platelets in mouse models of regenerative thrombocytopenia. Cells. 2023. 12:2419. https://doi.org/10.3390/cells12192419

Haake M, Haack B, Schäfer T, Harter PN, Mattavelli G, Eiring P, Vashist N, Wedekink F, Genssler S, Fischer B, Dahlhoff J, Mokhtari F, Kuznika A, Welters MJP, Benz TM, Sorger L, Thiemann V, Almanzar G, Selle M, Thein K, Späth J, Gonzalez MC, Reitinger C, Ipsen-Escobedo A, Wistuba-Hamprecht K, Eichler K, Filipski K, Zeiner PS, Beschorner R, Goedemans R, Gogolla FH, Hackl H, Rooswinkel RW, Thiem A, Romer Roche P, Joshi H, Pühringer D, Wöckel A, Diessner JE, Rüdiger M, Leo E, Cheng PF, Levesque MP, Goebeler M, Sauer M, Nimmerjahn F, Schuberth-Wagner C, von Felten S, Mittelbronn M, Mehling M, Beilhack A, van der Burg SH, Riedel A, Weide B, Dummer R, Wischhusen J. Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment. Nat Commun. 2023. 14:4253. https://doi.org/10.1038/s41467-023-39817-3

Pichler R, Diem G, Hackl H, Koutnik J, Mertens LS, D’Andrea D, Pradere B, Soria F, Mari A, Laukhtina, Krajewski W, Teoh J, Del Giudice F, Moschini M, Thurnher M, Posch W. Intravesical BCG in bladder cancer induces innate immune responses against SARS-CoV-2. Front Immunol. 2023. 14:1202157. https://doi.org/10.3389/fimmu.2023.1202157

Obermoser K, Brigo N, Schroll A, Monfort-Lanzas P, Gostner JM, Engl S, Geisler S, Knoll M, Schennach H, Weiss G, Fuchs D, Bellmann-Weiler R, Kurz K. Positive effects of probiotic therapy in patients with post-infectious fatigue. Metabolites. 2023. 13:639. https://doi.org/10.3390/metabo13050639

Gollmann-Tepeköylü C, Graber M, Hirsch J, Mair S, Naschberger A, Pölzl L, Nägele F, Kirchmair E, Degenhart G, Demetz E, Hilbe R, Chen HY, Engert JC, Böhm A, Franz N, Lobenwein D, Lener D, Fuchs C, Weihs A, Töchterle S, Vogel GF, Schweiger V, Eder J, Pietschmann P, Seifert M, Kronenberg F, Coassin S, Blumer M, Hackl H, Meyer D, Feuchtner G, Kirchmair R, Troppmair J, Krane M, Weiss G, Tsimikas S, Thanassoulis G, Grimm M, Rupp B, Huber LA, Zhang SY, Casanova JL, Tancevski I, Holfeld J. Toll-like receptor 3 mediates aortic stenosis via a conserved mechanism of calcification. Circulation. 2023. 147:1518-1533. https://doi.org/10.1161/circulationaha.122.063481

Wieser V, Tsibulak I, Reimer D, Zeimet AG, Fiegl H, Hackl H, Marth C. An angiogenic tumor phenotype predicts poor prognosis in ovarian cancer. Gynecol Oncol. 2023. 170:290-299. https://doi.org/10.1016/j.ygyno.2023.01.034

Starlinger P, Brunnthaler L, McCabe C, Pereyra D, Santol J, Steadman J, Hackl M, Skalicky S, Hackl H, Gronauer R, O’Brien D, Kain R, Hirsova P, Gores GJ, Wang C, Gruenberger T, Smoot RL, Assinger A. The transcriptomic landscapes of effective and failed liver regeneration in humans. JHEP Rep. 2023. 5:100683. https://doi.org/10.1016/j.jhepr.2023.100683

Vijver SV, Danklmaier S, Pipperger L, Gronauer R, Floriani G, Hackl H, Das K, Wollmann G. Prediction and validation of murine MHC class I epitopes of the recombinant virus VSV-GP. Front Immunol. 2023. 13:1100730. https://doi.org/10.3389/fimmu.2022.1100730

2022

Monfort-Lanzas P, Gronauer R, Madersbacher L, Schatz C, Rieder D, Hackl H. MIO: MicroRNA target analysis system for Immuno-Oncology. Bioinformatics. 2022. 38:3665-3667. https://doi.org/10.1093/bioinformatics/btac499

De la Cruz-Ku G, Aizpuru M, Hackl H, Ubl DS, Habermann E, Pery R, Driedger M, Assinger A, Nagorney D, Cleary S, Smoot R, Starlinger P. Hepatocellular carcinoma as predominant cancer subgroup accounting for sex differences in post-hepatectomy liver failure, morbidity and mortality. HPB. 2022. 24:1453-1463. https://doi.org/10.1016/j.hpb.2022.02.009

Schrottmaier WC, Pirabe A, Pereyra D, Heber S, Hackl H, Schmuckenschlager A, Brunnthaler L, Santol J, Kammerer K, Oosterlee J, Pawelka E, Treiber SM, Khan AO, Pugh M, Traugott MT, Schoergenhofer C, Seitz T, Karolyi M, Jilma B, Rayes J, Zoufaly A, Assinger A. Platelets and anti-platelet medication in COVID-19 related thrombotic complications. Front Cardiovasc Med. 2022. 8:802566. http://dx.doi.org/10.3389/fcvm.2021.802566

Duurland CL, Santegoets SJ, Abdulrahman Z, Loof NM, Sturm G, Wesselink TH, Arens R, Boekestijn S, Ehsan I, van Poelgeest MIE, Finotello F, Hackl H, Trajanoski Z, ten Dijke P, Braud VM, Welters MJP, van der Burg SH. CD161 expression and regulation defines rapidly responding effector CD4+ T cells associated with improved survival in HPV16-associated tumors. J Immunother Cancer. 2022. 10:e003995. http://dx.doi.org/10.1136/jitc-2021-003995

2021

Schrottmaier WC, Pirabe A, Pereyra D, Heber S, Hackl H, Schmuckenschlager A, Brunnthaler L, Santol J, Kammerer K, Oosterlee J, Pawelka E, Treiber SM, Khan AO, Pugh M, Traugott MT, Schoergenhofer C, Seitz T, Karolyi M, Jilma B, Rayes J, Zoufaly A, Assinger A. Adverse outcome in COVID-19 is associated with an aggravating hypo-responsive platelet phenotype. Front Cardiovasc Med. 2021. 8:795624. https://doi.org/10.3389/fcvm.2021.795624

Karbon G, Haschka M, Hackl H, Rocamora-Reverte L, Parson W, Fiegl H, Soratroi C, Villunger A. The BH3-only protein NOXA serves as an independent predictor of breast cancer patient survival and defines susceptibility to microtubule targeting agents. Cell Death Dis. 2021. 12:1151. https://doi.org/10.1038/s41419-021-04415-y

Posch W, Bermejo-Jambrina M, Steger M, Witting C, Diem G, Hörtnagl P, Hackl H, Lass-Floerl C, Huber LA, Geijtenbeek T, Wilflingseder D. Complement potentiates immune sensing of HIV-1 and early type I IFN responses. mBio. 2021. 12:e0240821. https://doi.org/10.1128/mbio.02408-21

Niederwieser T, Braunwarth E, Dasari BVM, Pufal K, Szatmary P, Hackl H, Haselmann C, Connolly CE, Cardini B, Öfner D, Roberts K, Malik H, Stättner S, Primavesi F. Arterial lactate concentrations early after liver resection stratify risk of post-hepatectomy liver failure and associated other complications. Brit J Surg. 2021. 108:1360-1370. https://doi.org/10.1093/bjs/znab338

Resch T, Hackl H, Esser H, Guenther J, Schwelberger H, Ritschl P, Ebner S, Maglione M, Mellitzer V, Biebl M, Oellinger R, Zoller H, Schneeberger S, Kotsch K. Expression of MICA in zero hour biopsies predicts graft survival after liver transplantation. Front Immunol. 2021. 12:606146. https://doi.org/10.3389/fimmu.2021.606146

Jonas JP, Hackl H, Pereyra D, Santol J, Ortmayr G, Rumpf B, Najarnia S, Schauer D, Brostjan C, Gruenberger T, Starlinger P. Circulating metabolites as a concept beyond tumor biology determining disease recurrence after resection of colorectal liver metastasis. HPB. 2021. 24:116-129. https://doi.org/10.1016/j.hpb.2021.06.415

Starlinger P, Ahn J, Mullan A, Gyoeri G, Pereyra D, Alva-Ruiz R, Hackl H, Reiberger T, Trauner M, Santol J, Simbrunner B, Mandorfer M, Berlakovich GA, Kamath PS, Heimbach J. The addition of C-reactive protein and von Willebrand factor to MELD-Na improves prediction of waitlist mortality. Hepatology. 2021. 74:1533-1545. https://doi.org/10.1002/hep.31838

Puhr M, Eigentler A, Handle F, Hackl H, Ploner C, Heidegger I, Schaefer G, Brandt M, Hoefer J, van der Pluijm G, Klocker H. Targeting the glucocorticoid receptor signature gene Mono Amine Oxidase-A enhances the efficacy of chemo- and anti-androgen therapy in advanced prostate cancer. Oncogene. 2021. 40:3087-3100. https://doi.org/10.1038/s41388-021-01754-0

Grandits A, Nguyen C, Schlerka A, Hackl H, Sill H, Etzler J, Heyes E, Stoiber D, Grebien F, Heller G, Wieser R. Down-regulation of MTSS1 in acute myeloid leukemia is associated with a poor prognosis, chemotherapy resistance, and disease aggressiveness. Leukemia. 2021. 35:2827-2839. https://doi.org/10.1038/s41375-021-01224-2

Messner F, Etra JW, Shores JT, Thoburn CJ, Hackl H, Lozano MI, Fidder SAJ, Guo Y, Kambarashvili K, Alagol K, Kalsi R, Cooney C, Furtmüller GJ, Krapf J, Oh BC, Brandacher G. Non-invasive evaluation of intragraft immune responses in upper extremity transplantation. Transpl Int. 2021. 34:894-905. https://doi.org/10.1111/tri.13854

Starlinger P, Ubl DS, Hackl H, Starlinger J, Nagorney DM, Smoot RL, Habermann EB, Cleary SP. The combined APRI/ALBI score to predict mortality after hepatic resection. BJS open. 2021. 5:zraa043. https://doi.org/10.1093/bjsopen/zraa043

2020

Alkan HF, Vesely PW, Hackl H, Foßelteder J, Schmidt DR, Vander Heiden MG, Pichler M, Hoefler G, Bogner-Strauss JG. Deficiency of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis. Cancer Metab. 2020. 8:26. https://doi.org/10.1186/s40170-020-00232-7

Tsibulak I, Wieser V, Welponer H, Leitner K, Hackl H, Marth C, Fiegl H, Zeimet AG. Clinical impact of BRCA2 mRNA expression in high-grade serous ovarian cancer: Validation using the TCGA cohort. Acta Oncol. 2020. 60:187-190. https://doi.org/10.1080/0284186x.2020.1841288

Starlinger P, Pereyra D, Hackl H, Orthmayer G, Braunwarth E, Santol J, Najarnia S, Driedger M, Gregory L, Alva-Rui R, Glasgow A, Assinger A, Nagorney D, Habermann E, Staetttner S, Cleary S, Smoot R, Gruenberger T. Consequences of perioperative serotonin reuptake inhibitor treatment during hepatic surgery. Hepatology. 2021. 73:1956-1966. https://doi.org/10.1002/hep.31601

Huemer F, Piringer G, Schlintl V, Hackl H, Rinnerthaler G, Thaler J, Greil R, Weiss L. Hospitalizations and clinical outcome in metastatic colorectal cancer during regorafenib or TAS-102 therapy. Cancers. 2020. 12:2812. https://doi.org/10.3390/cancers12102812

Hautz T, Messner F, Weissenbacher A, Hackl H, Kumnig M, Ninkovic M, Berchtold V, Krapf J, Zelger BG, Zelger B, Wolfram D, Pierer G, Löscher W, Zimmermann R, Gabl M, Arora R, Brandacher G, Öfner D, Schneeberger S. Long-term outcome after hand and forearm transplantation. Transpl Int. 2020. 33:1762-1778. https://doi.org/10.1111/tri.13752

Schlick K, Hohla F, Hamacher F, Hackl H, Hufnagl C, Magnes T, Gampenrieder SP, Melchardt T, Stättner S, Hauser-Kronberger C, Greil R, Rinnerthaler G. Overcoming negative predictions of microRNA expressions with FOLFIRINOX in advanced pancreatic cancer patients. Future Sci OA. 2020. 7:FSO644. https://doi.org/10.2144/fsoa-2020-0128

Gollmann-Tepeköylü C, Nägele F, Graber M, Pölzl L, Lobenwein D, Hirsch J, An A, Irschick R, Roehrs BT, Kremser C, Hackl H, Huber R, Venezia S, Hercher D, Fritsch H, Bonaros N, Stefanova N, Tancevski I, Meyer D, Grimm M, Holfeld J. Shock waves promote spinal cord repair via TLR3. JCI insight. 2020. 5:134552. https://doi.org/10.1172/jci.insight.134552

Rinnerthaler G, Gampenrieder SP, Hackl H, Steiner M, Monzo-Fuentes C, Melchardt T, Magnes T, Huemer F, Westphal T, Hufnagl C, Hauser-Kronberger C, Egle A, Greil R. Low expression of miR-20a-5p predicts benefit to bevacizumab in metastatic breast cancer patients treated within the TANIA phase III trial. J Clin Med. 2020. 9:E1663. https://doi.org/10.3390/jcm9061663

Moosbrugger-Martinz V, Hackl H, Gruber R, Pilecky M, Knabl L, Orth-Höller D, Dubrac S. First evidences of distinguishable bacterial and fungal dysbiosis in the skin of patients with Atopic Dermatitis or Netherton Syndrome. J Invest Dermatol. 2021. 141:114-123. https://doi.org/10.1016/j.jid.2020.05.102

Wieser V, Azim SA, Sprung S, Knoll K, Kögl J, Hackl H, Marth C, Zeimet AG, Fiegl H. TNF signalling predicts poor prognosis of patients with endometrial cancer. Carcinogenesis. 2020. 41:1065-1073. https://doi.org/10.1093/carcin/bgaa034

Gollmann-Tepeköylü C, Graber M, Pölzl L, Nägele F, Moling R, Esser H, Summerer B, Mellitzer V, Ebner S, Hirsch J, Schäfer G, Hackl H, Cardini B, Oberhuber R, Primavesi F, Öfner D, Bonaros N, Troppmair J, Grimm M, Schneeberger S, Holfeld J*, Resch *. Toll-like receptor 3 mediates ischaemia/reperfusion injury after cardiac transplantation. Eur J Cardiothorac Surg. 2020. 57:826-835. https://doi.org/10.1093/ejcts/ezz383

Welponer H, Tsibulak I, Wieser V, Degasper C, Shivalingaiah G, Wenzel S, Sprung S, Marth C, Hackl H, Fiegl H, Zeimet AG. The miR-34 family and its clinical significance in ovarian cancer. J Cancer. 2020. 11:1446-1456. https://doi.org/10.7150/jca.33831

Zeidner JF, Knaus HA, Zeidan AM, Blackford AL, Montiel-Esparza R, Hackl H, Prince GT, Gondek LP, Ghiaur G, Showel MM, DeZern AE, Pratz KW, Smith BD, Levis MJ, Gore S, Coombs CC, Foster MC, Streicher H, Karp JE, Luznik L, Gojo I. Immunomodulation with pomalidomide at early lymphocyte recovery after induction chemotherapy in newly diagnosed AML and high-risk MDS. Leukemia. 2020. 34:1563-1576. https://doi.org/10.1038/s41375-019-0693-4

2019

Nguyen CH, Bauer K, Hackl H, Schlerka A, Koller E, Hladik A, Stoiber D, Zuber J, Staber PB, Hoelbl-Kovacic A, Purton LE, Grebien F, Wieser R. All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia. Cell Death Dis. 2019. 10:944. https://doi.org/10.1038/s41419-019-2172-2

Glüxam T, Grandits AM, Schlerka B, Nguyen CH, Etzler J, Finkes T, Fuchs M, Scheid C, Heller G, Hackl H, Harrer N, Sill H, Koller E, Stoiber D, Sommergruber W, Wieser R. CGRP signaling via CALCRL increases chemotherapy resistance and stem cell properties in acute myeloid leukemia. Int J Mol Sci. 2019. 20:5826. https://doi.org/10.3390/ijms20235826

Györi GP, Pereyra D, Rumpf B, Hackl H, Köditz C, Fuxsteiner J, Ortmayr G, Reiberger T, Trauner M, Berlakovich GA, Starlinger P. Von Willebrand factor facilitates MELD-independent risk stratification on the waiting list for liver transplantation. Hepatology. 2020. 72:584-594. https://doi.org/10.1002/hep.31047

Finotello F, Rieder D, Hackl H, Trajanoski Z. Next-generation computational tools for interrogating cancer immunity. Nat Rev Genet. 2019. 20:724-746. https://doi.org/10.1038/s41576-019-0166-7

Messner F, Etra JW, Haugen CE, Bösmüller C, Maglione M, Hackl H, Riedmann M, Oberhuber R, Cardini B, Resch T, Scheidl S, Margreiter R, Öfner D, Schneeberger S, Margreiter C. Sex matching does not impact the outcome after simultaneous pancreas kidney transplantation. Clin Transplant. 2019. 33:e13717. https://doi.org/10.1111/ctr.13717

Leopold B, Strutz J, Weiß E, Gindlhuber J, Birner-Gruenberger R, Hackl H, Appel HM, Cvitic S, Hiden U. Outgrowth, proliferation, viability, angiogenesis and phenotype of primary human endothelial cells in different purchasable endothelial culture media: Feed wisely. Histochem Cell Biol. 2019. 152:377-390. https://doi.org/10.1007/s00418-019-01815-2

Tepeköylü C, Pölzl L, Graber M, Hirsch J, Nägele, Lobenwein D, Hess MW, Blumer MJ, Kirchmair E, Zipperle J, Hromada C, Hackl H, Hermann M, Al Khamisi H, Förster M, Lichtenauer M, Mittermayr R, Paulus P, Fritsch H, Bonaros N, Kirchmair R, Sluijter JPG, Davidson S, Grimm M, Holfeld J. miR-19a-3p containing exosomes improve function of ischemic myocardium upon shock wave therapy. Cardiovasc Res. 2019. 116:1226-1236. https://doi.org/10.1093/cvr/cvz209

Huemer F, Lang D, Westphal T, Gampenrieder SP, Hutarew G, Weiss L, Hackl H, Lamprecht B, Rinnerthaler G, Greil R. Baseline absolute lymphocyte count and ECOG performance score are associated with survival in advanced non-small cell lung cancer undergoing PD-1/PD-L1 blockade. J Clin Med. 2019. 8:1014. https://doi.org/10.3390/jcm8071014

Nguyen CH, Glüxam T, Schlerka A, Bauer K, Grandits AM, Hackl H, Dovey O, Zöchbauer-Müller S, Cooper JL, Vassiliou GS, Stoiber D, Wieser R, Heller G. SOCS2 is part of a highly prognostic 4-gene signature in AML and promotes disease aggressiveness. Sci Rep. 2019. 9:9139. https://doi.org/10.1038/s41598-019-45579-0

Wieser V, Sprung S, Tsibulak I, Haybaeck J, Hackl H, Fiegl H, Marth C, Zeimet AG. Clinical impact of RANK signalling in ovarian cancer. Cancers. 2019. 11:791. https://doi.org/10.3390/cancers11060791

Huemer F, Schlintl V, Hecht S, Hackl H, Melchardt T, Rinnerthaler G, Greil R, Weiss L. Regorafenib is associated with increased skeletal muscle loss compared to TAS-102 in metastatic colorectal cancer. Clin Colorectal Cancer. 2019. 18:159-166. https://doi.org/10.1016/j.clcc.2019.04.003

Finotello F, Mayer C, Plattner C, Laschober G, Rieder D, Hackl H, Krogsdam A, Loncova Z, Posch W, Wilflingseder D, Sopper S, Ijsselsteijn M, Brouwer TP, Johnson D, Xu Y, Wang Y, Sanders ME, Estrada MV, Ericsson-Gonzalez P, Charoentong P, Balko J, de Miranda N, Trajanoski Z. Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data. Genome Med. 2019. 11:34. https://doi.org/10.1186/s13073-019-0638-6

Plattner C, Hackl H. Modeling therapy resistance via the EGFR signaling pathway. FEBS J. 2019. 286:1284-1286. https://doi.org/10.1111/febs.14809

Starlinger P, Hackl H, Pereyra D, Skalicky S, Geiger E, Finsterbusch M, Tamandl D, Brostjan C, Grünberger T, Hackl M, Assinger A. Predicting Postoperative Liver Dysfunction Based on Blood Derived MicroRNA Signatures. Hepatology. 2019. 69:2636-2651. https://doi.org/10.1002/hep.30572

Schmidt F, Dahlke K, Batra A, Keye J, Wu H, Friedrich M, Glauben R, Ring C, Loh G, Schaubeck M, Hackl H, Trajanoski Z, Schumann M, Kühl AA, Blaut M, Siegmund B. Microbial colonization in adulthood shapes the intestinal macrophage compartment. J Crohns Colitis. 2019. 13:1173-1185. https://doi.org/10.1093/ecco-jcc/jjz036

Huemer F, Rinnerthaler G, Lang D, Hackl H, Lamprecht B, Greil R. Association between antibiotics use and outcome in patients with NSCLC treated with immunotherapeutics. Ann Oncol. 2019. 30:652-653. https://doi.org/10.1093/annonc/mdz021

2018

Schubert M, Hackl H, Gassner FJ, Greil R, Geisberger R. Investigating epigenetic effects of activation-induced deaminase in chronic lymphocytic leukemia. PLoS One. 2018. 13:e0208753. https://doi.org/10.1371/journal.pone.0208753

Strutz J, Cvitic S, Hackl H, Kashofer K, Appel HM, Thüringer A, Desoye G, Koolwijk P, Hiden U. Gestational diabetes alters microRNA signatures in human feto-placental endothelial cells depending on fetal sex. Clin Sci. 2018. 132:2437-2449. https://doi.org/10.1042/cs20180825

Knaus HA, Berglund S, Hackl H, Blackford AL, Zeidner JF, Montiel-Esparza R, Mukhopadhyay R, Vanura K, Blazar BR, Karp JE, Luznik L, Gojo I. Signatures of CD8+ T-cell dysfunction in AML patients and their reversibility with response to chemotherapy. JCI Insight. 2018. 3:120974. https://doi.org/10.1172/jci.insight.120974

Jakic B, Carlsson M, Buszko M, Cappellano G, Ploner C, Onestingel E, Foti M, Hackl H, Demetz E, Dietrich H, Wick C, Wick G. The effects of endurance exercise and diet on atherosclerosis in young and aged ApoE-/- and WT mice. Gerontology. 2019. 65:45-56. https://doi.org/10.1159/000492571

Xia W, Pessentheiner AR, Hofer D, Amor M, Schreiber R, Schoiswohl G, Eichmann TO, Valenta E, Itariu B, Prager G, Hackl H, Stulnig T, Kratky D, Rülicke R, Bogner-Strauss JG. Loss of Abhd15 impairs the anti-lipolytic action of insulin by altering PDE3B stability and contributes to insulin resistance. Cell Rep. 2018. 23:1948-1961. https://doi.org/10.1016/j.celrep.2018.04.055

Huemer F, Rinnerthaler G, Westphal T, Hackl H, Hutarew G, Gampenrieder SP, Weiss L, Greil R. Impact of antibiotic treatment on immune-checkpoint blockade efficacy in advanced non-squamous non-small cell lung cancer. Oncotarget. 2018. 9:16512-16520. https://doi.org/10.18632/oncotarget.24751

Efremova M, Rieder D, Klepsch V, Charoentong P, Finotello F, Hackl H, Hermann-Kleiter N, Löwer M, Baier G, Krogsdam AM, Trajanoski Z. Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution. Nat Commun. 2018. 9:32. https://doi.org/10.1038/s41467-017-02424-0

Huemer F, Thaler J, Piringer G, Hackl H, Pleyer L, Hufnagl C, Weiss L, Greil R. Sidedness and TP53 mutations impact OS in anti-EGFR but not anti-VEGF treated mCRC – an analysis of the KRAS registry of the AGMT (Arbeitsgemeinschaft Medikamentöse Tumortherapie). BMC Cancer. 2018. 18:11. https://doi.org/10.1186/s12885-017-3955-4

Gampenrieder SP, Rinnerthaler G, Hackl H, Pulverer W, Weinhaeusel A, Ilic S, Hufnagl C, Hauser-Kronberger C, Egle A, Risch A, Greil R. DNA methylation signatures predicting bevacizumab efficacy in metastatic breast cancer. Theranostics. 2018. 8:2278-2288. https://doi.org/10.7150/thno.23544

2017

Gamerith G, Rainer J, Huber JM, Hackl H, Trajanoski Z, Koeck S, Lorenz E, Kern J, Kofler R, Kelm JM, Zwierzina H, Amann A. 3D – cultivation of NSCLC cell lines induce gene expression alterations of key cancer-associated pathways and mimic in-vivo conditions. Oncotarget. 2017. 8:112647-112661. https://doi.org/10.18632/oncotarget.22636

Rammer M, Webersinke G, Haitchi-Petnehazy S, Maier E, Hackl H, Charoentong P, Malli T, Steinmair M, Petzer AL, Rumpold H. MicroRNAs and their Role for T stage Determination and Lymph Node Metastasis in Early Colon Carcinoma. Clin Exp Metastasis. 2017. 34:431-440. https://doi.org/10.1007/s10585-017-9863-9

Blunder S, Kõks S, Kõks G, Reimann E, Hackl H, Gruber R, Moosbrugger-Martinz V, Schmuth M, Dubrac S. Enhanced expression of genes related to xenobiotic metabolism in the skin of patients with atopic dermatitis but not with ichthyosis vulgaris. J Invest Dermatol. 2017. 138:98-108. https://doi.org/10.1016/j.jid.2017.08.036

Thöni V, Pfister A, Melmer A, Enrich B, Salzmann K, Kaser S, Lamina C, Ebenbichler CF, Hackl H, Tilg H, Moschen AR. Dynamics of bile acid profiles, GLP-1 and FGF19 after laparoscopic gastric banding. J Clin Endocrinol Metab. 2017. 102:2974-2984. https://doi.org/10.1210/jc.2017-00235

Weiss L, Melchardt T, Egle A, Hopfinger G, Hackl H, Greil R, Barth J, Rummel M. Influence of body mass index on survival in indolent and mantle cell lymphomas: analysis of the StiL NHL1 trial. Ann Hematol. 2017. 96:1155-1162. https://doi.org/10.1007/s00277-017-3003-0

Hackl H, Astania K, Wieser R. Molecular and genetic alterations associated with therapy resistance and relapse of acute myeloid leukemia. J Hematol Oncol. 2017. 10:51. https://doi.org/10.1186/s13045-017-0416-0

Günther J, Resch T, Hackl H, Sattler A, Ebner S, Ritschl PV, Biebl M, Öllinger R, Schneeberger S, Brandacher G, Schwelberger H, Zelger B, Stauch D, Pascher A, Pratschke J, Kotsch K. Identification of NKG2D as senescence marker in zero-hour kidney biopsies is indicative for clinical outcome. Kidney Int. 2017. 91:1447-1463. https://doi.org/10.1016/j.kint.2016.12.018

Charoentong P, Finotello F, Angelova M*, Mayer C, Efremova M, Rieder D, Hackl H, Trajanoski Z. Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade. Cell Rep. 2017. 18:248-262. https://doi.org/10.1016/j.celrep.2016.12.019

2016

Kammerer S, Sokolowski A, Hackl H, Platzer D, Jahn SW, El-Heliebi A, Schwarzenbacher D, Stiegelbauer V, Pichler M, Rezania S, Fiegl H, Peintinger F, Regitnig P, Hoefler G, Schreibmayer W, Bauernhofer T. KCNJ3 is a new independent prognostic marker for estrogen receptor positive breast cancer patients. Oncotarget. 2016. 7:84705-84717. https://doi.org/10.18632/oncotarget.13224

Wolf B, Goebel G, Hackl H, Fiegl H. Reduced mRNA expression levels of NFE2L2 are associated with poor outcome in breast cancer patients. BMC Cancer. 2016. 16:821. https://doi.org/10.1186/s12885-016-2840-x

Lammirato A, Patsch K, Feiereisen F, Maly K, Nofziger C, Paulmichl M, Hackl H, Trajanoski Z, Valovka T, Huber LA, Vietor I. TIS7 induces transcriptional cascade of methylosome components required for muscle differentiation. BMC Biology. 2016. 14:95. https://doi.org/10.1186/s12915-016-0318-6

Rezania S, Kammerer S, Li C, Steinecker-Frohnwieser B, Gorischek A, DeVaney T, Verheyen S, Passegger CA, Tabrizi-Wiszy NG, Hackl H, Platzer D, Zarnani AM, Jahn SW, Malle E, Bauernhofer T, Schreibmayer W. Overexpression of KCNJ3 gene splice variants affects vital parameters of the malignant breast cancer cell line MCF-7 in an opposing manner. BMC Cancer. 2016. 16:628. https://doi.org/10.1186/s12885-016-2664-8

Hackl H, Charoentong P, Finotello F, Trajanoski Z. Computational genomics tools for dissecting tumor-immune cell interactions. Nat Rev Genet. 2016. 17:441-458. https://doi.org/10.1038/nrg.2016.67

Melchardt T, Hufnagl C, Weinstock DM, Kopp N, Neureiter D, Tränkenschuh W, Hackl H, Weiss L, Rinnerthaler G, Hartmann TN, Greil R, Weigert O, Egle A. Clonal evolution in relapsed and refractory diffuse large B-cell lymphoma is characterized by high dynamics of subclones. Oncotarget. 2016. 7:51494-51502. https://doi.org/10.18632/oncotarget.9860

Pichrtová M, Arc E, Stöggl W, Kranner I, Hájek T, Hackl H, Holzinger A. Formation of lipid bodies and fatty acid composition changes upon pre-akinete formation in arctic and antarctic Zygnema (Sygnematophyceae, Streptophyta) strains. FEMS Microbiol Ecol. 2016. 92:fiw096. https://doi.org/10.1093/femsec/fiw096

Moschen AR, Gerner RR, Wang J*, Klepsch V, Adolph TE, Reider SJ, Hackl H, Pfister A, Schilling J, Moser PL, Kempster SL, Swidsinski A, Orth-Höller D, Weiss G, Baines JF, Kaser A, Tilg H. Lipocalin 2 protects from inflammation and tumorigenesis associated with gut microbiota alterations. Cell Host Microbe. 2016. 19:455-469. https://doi.org/10.1016/j.chom.2016.03.007

Gampenrieder SP, Hufnagl C, Brechelmacher S, Huemer F, Hackl H, Rinnerthaler G, Romeder F, Monzo Fuentes C, Morre P, Hauser-Kronberger C, Mlineritsch B, Greil R. Endothelin-1 genetic polymorphism as predictive marker for bevacizumab in metastatic breast cancer. Pharmacogenomics J. 2016. 17:344–350. https://doi.org/10.1038/tpj.2016.25

Schafferer S, Khurana R, Refolo V, Venezia S, Sturm E, Piatti P, Hechenberger C, Hackl H, Kessler R, Willi M, Gstir R, Krogsdam A, Lusser A, Poewe W, Wenning GK, Hüttenhofer A, Stefanova N. Changes in the miRNA-mRNA regulatory network precede motor symptoms in a mouse model of multiple system atrophy: clinical implications. PLoS One. 2016. 11:e0150705. https://doi.org/10.1371/journal.pone.0150705

Rinnerthaler G, Hackl H, Gampenrieder SP, Hamacher F, Hufnagl C, Hauser-Kronberger C, Zehentmayr F, Fastner G, Sedlmayer F, Mlineritsch B, Greil R. MiR-16-5p is a stably-expressed housekeeping microRNA in breast cancer tissues from primary and metastatic sites. Int J Mol Sci. 2016. 17:156. https://doi.org/10.3390/ijms17020156

Angelova M, Charoentong P, Hackl H, Trajanoski Z. The colorectal cancer immune paradox revisited. Oncoimmunology. 2016. 5:e1078058. https://doi.org/10.1080/2162402x.2015.1078058

2015

Posch W, Steger M, Knackmuss U, Blatzer M, Baldauf HM, Doppler W, White TE, Hörtnagl P, Diaz-Griffero F, Lass-Flörl C, Hackl H, Moris A, Keppler OT, Wilflingseder D. Complement-opsonized HIV-1 overcomes restriction in dendritic cells. PLoS Pathog. 2015. 11:e1005005. https://doi.org/10.1371/journal.ppat.1005005

Blatzer M, Jukic E, Posch W, Schöpf B, Binder U, Steger M, Blum G, Hackl H, Gnaiger E, Lass-Flörl C, Wilflingseder D. Amphotericin B resistance in Aspergillus terreus is overpowered by co-application of pro-oxidants. Antioxid Redox Signal. 2015. 23:1424-1438. https://doi.org/10.1089/ars.2014.6220

Wolfram D, Hackl H, Eberhart N, Hautz T, Starzl R, Thuille N, Wachter T, Zelger B, Pierer G, Schneeberger S. Differentiation between vascularized composite allograft acute skin rejection and delayed type hypersensitivity reactions based on cytokine analysis. VCA. 2015. 2:9-16. https://doi.org/10.1080/23723505.2015.1044636

Angelova M, Charoentong P, Hackl H, Fischer M, Snajder R, Krogsdam AM, Waldner MJ, Bindea G, Mlecnik B, Galon J, Trajanoski Z. Characterization of the immunophenotypes and the antigenomes reveal distinct tumor escape mechanisms and novel targets for immunotherapy of colorectal cancers. Genome Biol. 2015. 16:64. https://doi.org/10.1186/s13059-015-0620-6

Heller G, Rommer A, Steinleitner K, Etzler J, Hackl H, Heffeter P, Tomasich E, Filipits M, Steinmetz B, Topakian T, Klingenbrunner S, Ziegler B, Spittler A, Zöchbauer-Müller S, Berger W, Wieser R. EVI1 promotes tumor growth via transcriptional repression of MS4A3. J Hematol Oncol. 2015. 8:28. https://doi.org/10.1186/s13045-015-0124-6

Li C, Rezania S, Kammerer S, Sokolowski A, Devaney T, Gorischek A, Jahn S, Hackl H, Groschner K, Windpassinger C, Malle E, Bauernhofer T, Schreibmayer W. Piezo1 forms mechanosensitive ion channels in the human MCF7 human breast cancer cell line. Sci Rep. 2015. 5:8364. https://doi.org/10.1038/srep08364

Perkhofer S, Zenzmaier C, Frealle E, Blatzer M, Hackl H, Sartori B, Lass-Flörl C. Differential gene expression in Aspergillus fumigatus induced by human platelets in vitro. Int J Med Microbiol. 2015. 305:327-338. https://doi.org/10.1016/j.ijmm.2015.01.002

Wolfram D, Morandi EM, Eberhart N, Hautz T, Hackl H, Zelger B, Riede G, Wachter T, Dubrac S, Ploner C, Pierer G, Schneeberger S. Differentiation between acute skin rejection in allotransplantation and Tcell mediated skin inflammation based on gene expression analysis. Biomed Res Int. 2015. 2015:259160. https://doi.org/10.1155/2015/259160

Wilflingseder D, Schroll A, Hackl H, Gallasch R, Frampton D, Pancino G, Sáez-Cirián A, Kellam P, Trajanoski Z, Geijtenbeek TB, Weiss G, Lass-Flörl C, Lambotte O, Weiss L, Posch W. Triggering CD11b/c on HIV-exposed DCs promotes immediate Th17 polarization. J Infect Dis. 2015. 212:44-56. https://doi.org/10.1093/infdis/jiv014

2014

Hautz T, Wolfram D, Eberhart N, Hackl H, Messner F, Weissenbacher A, Kimelman M, Zelger BG, Zelger B, Schneeberger S. The impact of skin type and area on skin rejection in limb transplantation. VCA. 2014. 1:42-49. https://doi.org/10.4161/23723505.2014.973795

Koller D, Hackl H, Bogner-Strauss JG, Hermetter A. Effects of oxidized phospholipids on gene expression in RAW 264.7 macrophages: A microarray study. PLoS One. 2014. 9:e110486. https://doi.org/10.1371/journal.pone.0110486

Hackl H, Steinleitner K, Lind K, Hofer S, Tosic N, Pavlovic S, Suvajdzic N, Sill H, Wieser R. A gene expression profile associated with relapse of cytogenetically normal acute myeloid leukemia is enriched for leukemia stem cell genes. Leuk Lymphoma. 2015. 56:1126-1128. https://doi.org/10.3109/10428194.2014.944523

Melchardt T, Troppan K, Weiss L, Hufnagl C, Neureiter D, Tränkenschuh W, Hopfinger G, Magnes T, Deutsch A, Neumeister P, Hackl H, Greil R, Pichler M, Egle A. A modified scoring of the NCCN-IPI is more accurate in the elderly and is improved by albumin and β2-microglobulin. Br J Haematol. 2014. 168:239-45. https://doi.org/10.1111/bjh.13116

Steinmetz B, Hackl H, Slabáková E, Schwarzinger I, Smejová M, Spittler A, Arbesu I, Shehata M, Souček K, Wieser R. The oncogene EVI1 enhances transcriptional and biological responses of human myeloid cells to all-trans retinoic acid. Cell Cycle. 2014. 13:2931-2943. https://doi.org/10.4161/15384101.2014.946869

Wolfram D, Starzl R, Hackl H, Barclay D, Hautz T, Zelger B, Brandacher G, Lee WPA, Eberhart N, Vodovotz Y, Pratschke J, Pierer G, Schneeberger S. Insights from Computational Modeling in Inflammation and Acute Rejection in Limb Transplantation. PLoS One. 2014. 9:e99926. https://doi.org/10.1371/journal.pone.0099926

Tymoszuk P, Charoentong P, Hackl H, Spilka R, Müller-Holzner E, Trajanoski Z, Obrist P, Revillion F, Fiegl H, Doppler W. High STAT1 mRNA levels but not its tyrosine phosphorylation are associated with macrophage infiltration and bad prognosis in breast cancer. BMC Cancer. 2014. 14:257. https://doi.org/10.1186/1471-2407-14-257

2013

Gallasch R, Efremova M, Charoentong P, Hackl H, Trajanoski Z. Mathematical models for translational and clinical oncology. J Clin Bioinforma. 2013. 3:23. https://doi.org/10.1186/2043-9113-3-23

Cvitic S, Longtine MS, Hackl H, Wagner K, Nelson MD, Desoye G, Hiden U. The human placental sexome differs between trophoblast epithelium and villous vessel endothelium. PLoS One. 2013. 8:e79233. https://doi.org/10.1371/journal.pone.0079233

Walenta E, Pessentheiner AR, Pelzmann HJ, Deutsch A, Goeritzer M, Kratky D, Hackl H, Oh DY, Prokesch A, Bogner-Strauss JG. α/β-hydrolase domain containing protein 15 (Abhd15): an adipogenic gene protecting from apoptosis. PLoS One. 2013. 8:e79134. https://doi.org/10.1371/journal.pone.0079134

Rommer A, Steinleitner K, Hackl H, Schneckenleithner C, Engelmann M, Scheideler M, Vlatkovic I, Vanura K, Kralovics R, Cerny-Reiterer S, Valent P, Sill H, Wieser R. Overexpression of primary microRNA 221/222 in acute myeloid leukemia. BMC Cancer. 2013. 13:364. https://doi.org/10.1186/1471-2407-13-364

Snajder R, Trajanoski Z, Hackl H. GPViz: dynamic visualization of genomic regions and variants affecting protein domains. Bioinformatics. 2013. 29:2195-2196. https://doi.org/10.1093/bioinformatics/btt354

Kienesberger PC, Pulinilkunnil T, Nagendran J, Young ME, Bogner-Strauss JG, Hackl H, Khadour R, Heydari E, Haemmerle G, Zechner R, Kershaw EE, Dyck JRB. Early structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablation. Cardiovasc Res. 2013. 99:442-451. https://doi.org/10.1093/cvr/cvt124

Rommer A, Steinmetz B, Herbst F, Hackl H, Heffeter P, Heilos D, Filipits M, Steinleitner K, Hemmati S, Herbacek I, Schwarzinger I, Hartl K, Rondou P, Glimm H, Karakaya K, Krämer A, Berger W, Wieser R. EVI1 inhibits apoptosis induced by antileukemic drugs via upregulation of CDKN1A/p21/WAF in human myeloid cells. PLoS One. 2013. 8:e56308. https://doi.org/10.1371/journal.pone.0056308

Duszka K, Bogner-Strauss JG, Hackl H, Rieder D, Neuhold C, Prokesch A, Trajanoski Z, Krogsdam AM. Nr4a1 is required for fasting-induced Pparg2 down regulation in white adipose. Mol Endocrinol. 2013. 27:135-149. https://doi.org/10.1210/me.2012-1248

2012

Villar D, Ortiz-Barahona A, Gómez-Maldonado L, Pescador N, Sánchez-Cabo F, Hackl H, Rodriguez BA, Trajanoski Z, Dopazo A, Huang TH, Yan PS, Del Peso L. Cooperativity of Stress-Responsive Transcription Factors in Core Hypoxia-Inducible Factor Binding Regions. PLoS One. 2012. 7:e45708. https://doi.org/10.1371/journal.pone.0045708

Charoentong P, Angelova M, Efremova M, Gallasch R, Hackl H, Galon J, Trajanoski Z. Bioinformatics for Cancer Immunology and Immunotherapy. Cancer Immunol Immunother. 2012. 61:1885-903. https://doi.org/10.1007/s00262-012-1354-x

Lassance L, Miedl H, Konya V, Heinemann A, Ebner B, Hackl H, Desoye G, Hiden U. Differential response of arterial and venous endothelial cells to extracellular matrix is modulated by oxygen. Histochem Cell Biol. 2012. 137:641-655. https://doi.org/10.1007/s00418-012-0917-4

2011

Augsten M, Hackl H, Ebner B, Chemelli A, Glatter O, Marsche G, Lang U, Desoye G, Wadsack C. Fetal HDL/apoE: A novel regulator of gene expression in human placental endothelial cells. Physiol Genomics. 2011. 43:1255-1262. https://doi.org/10.1152/physiolgenomics.00109.2011

Hakim-Weber R, Krogsdam AM, Jørgensen C, Fischer M, Prokesch A, Bogner-Strauss JG, Bornstein SR, Hansen JB, Madsen L, Kristiansen K, Trajanoski Z, Hackl H. Transcriptional regulatory program in wild-type and retinoblastoma gene-deficient mouse embryonic fibroblasts during adipocyte differentiation. BMC Res Notes. 2011. 4:157. https://doi.org/10.1186/1756-0500-4-157

Pinent M, Prokesch A, Hackl H, Voshol PJ, Klatzer A, Walenta E, Panzenböck U, Kenner L, Trajanoski Z, Höfler G, Bogner-Strauss JG. Adipose triglyceride lipase and hormone-sensitive lipase are involved in fat loss in JunB-deficient mice. Endocrinology. 2011. 152:2678-2689. https://doi.org/10.1210/en.2010-1477

Sanchez-Cabo F, Rainer J, Dopazo A, Trajanoski Z, Hackl H. Insights into global mechanisms and disease by gene expression profiling. Methods Mol Biol. 2011. 719:269-98. https://doi.org/10.1007/978-1-61779-027-0_13

Prokesch A, Bogner-Strauss JG, Hackl H, Rieder D, Neuhold C, Walenta E, Krogsdam A, Scheideler M, Papak C, Wong WC, Vinson C, Eisenhaber F, Trajanoski Z. Arxes: Retrotransposed genes required for adipogenesis. Nucl Acids Res. 2011. 39:3224-3239. https://doi.org/10.1093/nar/gkq1289

2010

Hackl H, Stocker G, Pornpimol C, Mlecnik B, Bindea G, Galon J, Trajanoski Z. Information technology solutions for integration of biomolecular and clinical data in the identification of new cancer biomarkers and targets for therapy. Pharmacol Ther. 2010. 128:488-498. https://doi.org/10.1016/j.pharmthera.2010.08.012

Hackl H, Rommer A, Konrad TA, Nassimbeni C, Wieser R. Tetracycline regulator expression alters the transcriptional program of mammalian cells. PLoS One. 2010. 5:e13013. https://doi.org/10.1371/journal.pone.0013013

Bogner-Strauss JG, Prokesch A, Sanchez-Cabo F, Rieder D, Hackl H, Duszka K, Krogsdam A, Di Camillo B, Walenta E, Klatzer A, Lass A, Pinent M, Wong WC, Eisenhaber F, Trajanoski Z. Reconstruction of gene association network reveals a transmembrane protein required for adipogenesis and targeted by PPARg. Cell Mol Life Sci. 2010. 67:4049-4064. https://doi.org/10.1007/s00018-010-0424-5

Nusshold C, Kollroser M, Koefeler H, Rechberger G, Reicher H, Uellen A, Bernhart E, Waltl S, Kratzer I, Hermetter A, Hackl H, Trajanoski Z, Hrzenjak A, Malle E, Sattler W. Hypochlorite-modification of sphingomyelin generates chlorinated lipid species that induce apoptosis and proteome alterations in dopaminergic PC12 neurons in vitro. Free Radic Biol Med. 2010. 48:1588-1600. https://doi.org/10.1016/j.freeradbiomed.2010.02.037

Wieser R, Scheideler M, Hackl H, Engelmann M, Schneckenleithner C, Hiden K, Papak C, Trajanoski Z, Sil H, Fonatsch C. microRNAs in acute myeloid leukemia: expression patterns, correlations with genetic and clinical parameters, and prognostic significance. Genes Chromosomes Cancer. 2010. 49:193-203. https://doi.org/10.1002/gcc.20740